The purpose of this study was to examine the predictability of employee’s organizational commitment from the personality traits, self-esteem and quality of life. The statistical population was the personnel of Ministry of Education in Qom province. A sample size of 141 individuals were selected with stratified the random sampling method (depending on the type of employment). Research method was descriptive- correlation. To collect the data Eysenck personality questionnaire (EPQ), self-esteem Eysenck questionnaire (ESQ), SF-36 quality of life questionnaire and organizational commitment questionnaire (OCQ) were used. The data were analyzed through Pearson correlation coefficient and multiple regression analysis. The results showed significant relations between personality characteristics and organizational commitment (P<0.01), self-esteem and organizational commitment (P<0.01, quality of life and organizational commitment (P<0.05). Also significant relationships were found between personality characteristics and self-esteem (P<0.01); between personality characteristics and quality of life (P<0.05) and between quality of life and self esteem (P<0.01). Three dimensions of energy, mental health and social performance of the eight dimensions of quality of life were also able to predict organizational commitment (P<0.05). Based on the results of this study we proposed organizations use the tests of personality characteristics, self-esteem and quality of life in order to promote commitment and efficiency of the staff.